Clonazepam decreases my sleepwalking

Clonazepam is one of the "standard" drug used to treat sleepwalking so it was the ideal starting point to see how it affects my sleepwalking but also to verify that my scoring approaches could capture the drug effect.

Clonazepam decreases my sleepwalking
As the graphs below show, Clonazepam at a dose of 1mg shows a trend toward a 20% reduction of the number of sleepwalking event per night (see graph A below) (more on data representation here).
But those are just trend as none of those values are statically significant.

Average values, +/- SEM. % variation and statistical significance are indicated (if less than 1%)

Interestingly with a dose 50% higher (1.5mg) the number of events and their average intensity are statistically reduced (see graphs G to L below).

Average values, +/- SEM. % variation and statistical significance are indicated (if less than 1%)

This is particularly relevant considering that this data set has even less nights in it compared to the 1mg data set.
It would of course be very interesting to see if an even higher dose of clonazepam would be even more effective.The problem is that 1 day after taking 1.5mg of clonazepam I still see a statistically significant decrease of the number of sleepwalking events per night, as graphs M below shows.

Average values, +/- SEM. % variation and statistical significance are indicated (if less than 1%)

This is most likely because clonazepam having a 30-40h half life (see on page 2 of this doc) I still have significantly enough of it in my body the second night to be effective.
One can only wonder then how much clonazepam impairs my daily activities between those 2 nights. And just because of that clonazepam can never become a regular treatment of my sleepwalking, even if it reduces it 100% at a higher dose.
Interestingly there is no clonazepam effect on the 3rd night (so about 48h after taking it), as the graphs S to X below show.

Average values, +/- SEM. % variation and statistical significance are indicated (if less than 1%)

Finding the right drug timing:
Because clonazepam has a plasma peak level of about 1-2h and because of the data in graph H suggesting that clonazepam is most active later in the night, I looked for a potential correlation between the BCSL for each event and the amount of time since taking the drug. As the graph showed below there is no correlation, suggesting that the drug was taken early enough before falling asleep to not "miss" the first sleepwalking events of that night:

Avoiding drug tolerance
Also because chronic use of clonazepam can lead to the development of tolerance (same drug dose becoming less effective) I limited my drug use to every 4 days at the minimum, since clonazepam half-life is about 30-40h.
I also verified that there was no correlation between the BCSL of each night and the number of days between doses of Clonazepam, as illustrated in the graph below:

Last updated: 23 Sept 2015